Efficacy Study of Vitamin D Supplementation to Meticillin Resistant Staphylococcus Aureus (MRSA) Carriers
The purpose of this study is to treat persistent MRSA carriers with vitamin D supplementation during a 12 month to see if the number of MRSA positive patients can be reduced.
Study InterventionsCholecalciferol, PlaceboPrimary EndpointsMRSAStudy Period2014-12 → 2017-12 Evaluation of the Inhibitory Effects of Topical Ivermectin on Markers of Rosacea Specific Inflammation.
This study will assess the role of topical Ivermectin 1% cream and its effect on protease and antimicrobial peptide expression and on the skin microbiome (the microorganisms that live on the skin) in rosacea. This is a single-site 16-week open-label study at University of California, San Diego. The investigators will do this by first measuring serine protease activity and cathelicidin and skin mic
Study InterventionsIvermectinPrimary EndpointsRelative Trypsin-like Enzyme ActivityStudy Period2016-07 → 2021-05 Therapeutic Benefit of Preoperative Supplemental Vitamin D in Patients Undergoing Major Surgical Procedures.
Vitamin D (Vitamin D) deficiency is very common. We recently showed that 97% of 204 patients admitted to Truman Medical Center were Vitamin D deficient (\<30 ng/ml). However, the consequences of Vitamin D deficiency, particularly with respect to infection, are not well understood. It is known that production of cathelicidin, an important antimicrobial peptide, is critically dependent upon Vitamin
Study InterventionsBlood draw pre-operatively, Blood draw post-operative Day 1, Blood draw post-operative Day 2Primary EndpointsChange in Vitamin D level as measured as 25-OHD levelStudy Period2016-02 → 2016-05 Effects of Vitamin D and Omega-3 Fatty Acids on Infectious Diseases and hCAP18 (VITAL Infection)
The VITamin D and OmegA-3 TriaL (VITAL; NCT 01169259) is an ongoing randomized clinical trial in 25,875 U.S. men and women investigating whether taking daily dietary supplements of vitamin D3 (2000 IU) or omega-3 fatty acids (Omacor® fish oil, 1 gram) reduces the risk of developing cancer, heart disease, and stroke in people who do not have a prior history of these illnesses. This ancillary study
Study Interventionsvitamin D3, omega-3 fatty acids (fish oil), Vitamin D3 placeboPrimary Endpointsupper respiratory infection; hCAP-18Study Period2010-07 → 2026-12 Vitamin D in Ventilated ICU Patients
The increasing rate of hospital-acquired infection and antibiotic resistance are major causes of prolonged ICU stay and death in hospitalized patients. The enormous impact of ICU-related infection demands the need for cost-effective therapies that can be rapidly implemented to improve patient immune response to control infection. Unfortunately, little high-quality comparative effectiveness researc
Study InterventionsEnteral Vitamin D3 50,000 IU, Enteral Vitamin D3 100,000IU, Inactive substancePrimary EndpointsNumber of Participants With Plasma 25(OH)D Concentration >30ng/mL at Baseline; Number of Participants With Plasma 25(OH)D Concentration >30ng/mL at Day 7Study Period2011-07 → 2014-04 Outcome of High Dose Vitamin D on Prognosis of Sepsis Requiring Mechanical Ventilation
There is a high prevalence of vitamin D deficiency in the critically ill patient population, with approximately 60% of patients found to be vitamin D deficient, (25(OH)D concentrations \<20 ng/mL) and an additional 30% of patients being vitamin D insufficient, (25(OH)D = 20-30 ng/mL).Approximately 80% of sepsis/septic shock patients experience respiratory failure and require mechanical ventilation
Study InterventionsVitamin D3 tablets, Vitamin D tabletsPrimary EndpointsChange in procalcitonin level (ng/ml) and antimicrobial peptide cathelicidin (LL37) (ng/ml) level at day 7.Study Period2022-03-01 → 2022-10-31 Effects of Aminocaproic Acid (ACA) on Rosacea-specific Inflammation
The purpose of this study is to determine the effect of topical aminocaproic acid on the immune system by assessing the levels of antimicrobial peptides in the skin of patients with rosacea. It is hypothesized that aminocaproic acid applied topically will alter the body's immune system in patients with rosacea by inhibiting activation of antimicrobial peptides.
Study InterventionsTopical aminocaproic acid (ACA) mixed with Vanicream, Vehicle creamPrimary EndpointsKallikrein 5 (KLK5) Protease ActivityStudy Period2011-07 → 2012-12 Peri-implant Vitamin D and Cathelicidin (LL-37) Levels
This research aims to explore the influence of vitamin D on the body's defense system by examining its impact on specific proteins involved in immune response and inflammation in the soft tissues surrounding dental implants. Also aims to determine how vitamin D levels affect these proteins and their role in protecting peri-implant tissues from microbial infections and inflammation.
Study InterventionsThe patients' periodontal clinical parameters were recorded. PISF samples were collected, and the evaluations of 25(OH)D and LL-37 were conducted using enzyme-linked immunosorbent assay.Primary EndpointsPeri-implant sulcus fluid vitamin D levels and clinical parameters correlation; The correlation between vitamin D and the antimicrobial peptide LL-37Study Period2021-04-01 → 2021-12-01 Periprosthetic Joint Infections: Diagnostic Accuracy and Cost-effectiveness Analysis of Serum and Synovial Markers
Total joint replacement (TJR) is an increasing effective procedure in orthopedics. However, TJR failure due to aseptic or septic loosening remains an important problem, often due to predisposing factors of the patient, which determine the need to perform a revision surgery. In light of the recent conclusions emerged on the still open problems concerning the diagnostic accuracy of serum and synovia
Primary EndpointsWhite blood cell count (WBC, cells/μL); Erythrocyte sedimentation rate (ESR, mm/hour)Study Period2022-02-01 → 2026-03-31 Clinical Trial of Phenylbutyrate and Vitamin D in Tuberculosis (TB)
Vitamin D exerts its effects via the Vitamin D Receptor (VDR) present in activated macrophages and induces expression and release of the cathelicidin, LL-37, a human antimicrobial peptide involved in killing of MTB. We aimed to investigate whether treatment of newly diagnosed pulmonary TB patients for 2 months with adjunctive PBA and vitamin D (Cholecalciferol) in combination with standard DOTS th
Study InterventionsActive Sodium Phenylbutyrate and active cholecalciferol, Placebo Sodium Phenylbutyrate plus active cholecalciferol, Active Sodium Phenylbutyrate and placebo cholecalciferolPrimary EndpointsProportion of pulmonary TB patients who are culture negative in sputum in week 4; Difference in improvement in clinical endpoints consisting of cough clearance, percentage chest x-ray clearance, fever remission and weight increase upto 8 weeks.Study Period2010-12 → 2014-12