Alpha-lipoic Acid/L-acetyl Carnitine for Progressive Supranuclear Palsy
Studies have shown that alpha-lipoic acid and L-acetyl carnitine may have some neuroprotective activities and it is hoped that they could be helpful for people with neurodegenerative illnesses such as progressive supranuclear palsy (PSP).
The purpose of this study is to find out whether the nutritional supplement alpha-lipoic acid/L-acetyl carnitine is safe and well-tolerated in individuals with
Study Interventionsalpha-lipoic acid and L-acetyl carnitinePrimary EndpointsAdverse EventsStudy Period2010-09-14 → 2015-04-07 L-carnitine for Fatigue in COPD
supplementation with L-carnitine that is available both as an FDA-approved therapy for primary carnitine deficiency, as well as widely available as an over-the-counter ergogenic aid will improve wellbeing and function measured by questionnaires in patient with chronic obstructive pulmonary disease (COPD).
based on our review of literature that addition of health coaching (HC) to L-carnitine will
Study InterventionsL-carnitine 1000 mg twice daily, Weekly health coaching calls, Placebo capsulesPrimary EndpointsChange in Exercise Capacity as Measured by the Six Minute Walk Test (6MWT)Study Period2017-01 → 2018-02 Effects of L-carnitine and Coenzyme Q10 Supplementation on Oxidative Stress in Tunisian Hemodialysis Patients.
The goal of this clinical trial was to learn if supplementation with L-carnitine or Coenzyme Q10 improves effectively the oxidative stress markers in adult patients undergoing chronic hemodialysis. It was also to evaluate the basic oxidative profile of hemodialyzed patients and to learn about the safety and tolerability of the two supplements. The main questions it aimed to answer are:
* Does tun
Study InterventionsOral administration of L-carnitine 1000 Mg, Oral administration of Coenzyme Q10 300Mg, placebo capsulesPrimary EndpointsOxidative stress parametersStudy Period2024-06-17 → 2024-11-30 MRI and Stable Isotope Tracer Studies for Detecting the Progression of Non-Alcoholic Steatohepatitis (NASH)
One-third of the world's population suffers from Non-Alcoholic Fatty Liver Disease (NAFLD), that is a disease with an accumulation of fat in the liver. Some patients with NAFLD will progress in their disease to develop inflammation, scarring of the liver tissue, and cirrhosis that can lead to liver failure. The mechanisms of the disease and its progression are still not fully understood. It is the
Study InterventionsMagnetic Resonance Imaging, Stable Isotope StudyPrimary EndpointsDifferences in whole-body fatty acid oxidation in a stable isotope labelled postprandial study day in participant groups.Study Period2020-03-01 → 2027-10-01 Comparing Blood Sugar Levels and Endothelial Function of PEAK ATP® With GlycoCarn®, PEAK ATP® and GlycoCarn® Supplements
To purpose of this study is to assess the effectiveness, safety and tolerability of PEAK ATP® with GlycoCarn®, PEAK ATP® and GlycoCarn® on levels of blood sugar and endothelial function improvement which may lead to improved vascular health.
Study InterventionsPEAK ATP® with GlycoCarn®, PEAK ATP®, GlycoCarn®Primary EndpointsMean change in plasma glucoseStudy Period2012-07 → 2016-04 Impact of Hemodialysis on Plasma Carnitine Levels in Patients With End Stage Renal Disease
OBJECTIVES
* To assess the levels of plasma carnitine in controls and hemodialysis patients.
* To give supplementary L-carnitine to study subjects for a duration of 5months.
* To compare the values of plasma carnitine before and after L carnitine supplementation.
* To assess the role of carnitine supplementation on biochemical and clinical parameters.
Study InterventionsL-Carnitine 500Mg thrice daily, 1g L-Carnitine IV three times a weekPrimary EndpointsL-Carnitine levels in hemodialysisStudy Period2023-01-01 → 2023-07-10 Compassionate Use of Triheptanoin (C7) for Inherited Disorders of Energy Metabolism
This is a compassionate use study to allow patients already taking triheptanoin (C7) through previous studies to continue to receive the supplement. It will also allow triheptanoin supplementation in patients with qualifying disorders if they are failing conventional therapy.
Study Interventionstriheptanoin Carnitine Supplementation in Pediatric Hemodialysis Patients
The goal of this study is:
1. To determine the prevalence of carnitine deficiency among pediatric patients on hemodialysis.
2. To evaluate the efficiency of carnitine supplementation in children on regular hemodialysis with carnitine deficiency in the treatment of renal anemia, cardiac dysfunction, dyslipidemia, intradialytic muscle cramps and hypotension and their quality of life.
Study InterventionsL-carnitine, isotonic salinePrimary Endpointschange in serum free carnitine level; change in cardiac functionsStudy Period2023-08-01 → 2024-03-01 A Pilot Study Investigating the Effects of Acetyl-L-Carnitine and Vincristine-Induced Neuropathy in Pediatric Patients With ALL
The purpose of this study is to see if a drug called Acetyl-L-Carnitine can help prevent painful nerve damage and nerve pain which is caused by vincristine, a drug used in chemotherapy in children being treated for newly diagnosed ALL. Acetyl-L-Carnitine is a drug available for purchase as a nutritional supplement but for the purpose of this study is experimental.
Study InterventionsAcetylcarnitine, PlaceboPrimary EndpointsGrade of Neurotoxicity Will be Captured by an Adaptation of the Total Peripheral Neuropathy Score.Study Period2009-09 → 2016-01 A Clinical Study on Efficacy & Safety Profile of Propionyl-L-carnitine Tablets for Peripheral Arterial Diseases
The main objective of this study is to evaluate the effectiveness and safety of the propionyl-L-carnitine hydrochloride tablets among Chinese population in comparison with the placebo, for treatment of the peripheral arterial diseases (intermittent claudication) with oral supplementation of 2g daily for a 4 months continuous administration.
Study InterventionsPropionyl-L-carnitine TabletsPrimary EndpointsTo compare the difference between pre-and post-the treatment of each groupStudy Period2008-05 → 2011-01