Menopur® Versus Follistim® in Polycystic Ovarian Syndrome (PCOS)
This multicenter, randomized, open-label exploratory study will be performed in approximately 200 polycystic ovary syndrome (PCOS) but otherwise healthy females undergoing in vitro fertilization (IVF). Each study center will follow its standard practice for in vitro fertilization (IVF) within the study parameters as noted in this protocol. The study centers will use marketed products purchased fro
Study InterventionsMenotropin, Progesterone vaginal insert, Follitropin betaPrimary EndpointsParticipants With Cycle Cancellation Due to Risk of Ovarian Hyperstimulation Syndrome (OHSS) Between Weeks 1 - 3Study Period2009-01 → 2010-09 Androgenic Profile Following Controlled Ovarian Stimulation
In this study the investigators will try to discover whether there is a difference for any of the stimulation preparations - recombinant FSH + recombinant LH (pergoveris \& luveris) vs. human menopausal gonadotropin (menopur) during GnRH-antagonist cycles in the meaning of androgenic hormones profile. The study question is whether using recombinant LH will result in different follicular hormonal m
Study Interventionsrecombinant gonadotropins, HP-HMGPrimary EndpointsSerum hormonal profile; Follicular fluid hormonal profileStudy Period2016-12 → 2020-01 A Study to Compare the Safety and Efficacy of Cetrotide® 3 Milligram (mg) Versus Antagon™ in Women Undergoing Ovarian Stimulation
To demonstrate the comparative safety and efficacy of Cetrotide® 3 milligram (mg) and Antagon™ in the inhibition of a premature luteinizing hormone (LH) surge in women undergoing ovarian stimulation with recombinant human follicle stimulating hormone/human menopausal gonadotropin (r-hFSH/hMG) prior to assisted reproductive technology (ART) and utilizing oral contraceptives pill (OCP) for cycle pro
Study InterventionsCetrotide®, Antagon ™, Recombinant human follicle stimulating hormone (r-hFSH)Primary EndpointsPercentage of subjects without premature luteinizing hormone (LH) surgeStudy Period2003-09 → 2004-05 Low Dose GnRHa Early Luteal Phase Down Regulation Versus GnRHa Ultra-short Protocol for Poor Ovarian Response
The management of the poor responder patients is very difficult. Currently, there is no any standard treatment for poor responder patients. The study is designed to test a modified GnRHa protocol for poor ovarian response, low dose GnRHa early luteal phase down regulation, compare with GnRHa ultra-short protocol. This is a randomized controlled trial.
Study InterventionsDiphereline (Triptorelin embonate), Decapeptyl (Triptorelin), human menopausal gonadotropinPrimary Endpointslive birthStudy Period2016-12 → 2020-12 Endometrial Injury and IVF Outcome Parameters in Patients With Failed IVF Cycles
The iatrogenic induction of local endometrial injury caused through hysteroscopy or pipelle sampling in the preceding non- transfer cycle improves the IVF outcome parameters in patients with previous IVF failures.
Study InterventionsEndometrial injury by hysteroscopy or pipelle sampling, Proceed to COH directlyPrimary Endpointspositive bHCG rateStudy Period2013-03 → 2016-06 Mild Stimulation Protocol Using Clomiphene Citrate for Women With PCOS Undergoing in Vitro Fertilization
Infertility is of increasing significance affecting almost 48.5 million couples around the world. Anovulation is a major cause of infertility in women with polycystic ovary syndrome (PCOS) accounting for about 80% of women with anovulatory infertility. Ultrasound morphological features of PCOS include the presence of 16 or more follicles measuring 2-9 mm in diameter, and/or an overall large ovaria
Study Interventionsmild stimulation protocol: oral Clomiphene Citrate, Conventional Stimulation Protocol: will receive FSH/HMGPrimary EndpointsLive birth rateStudy Period2023-06-01 → 2025-07-01 Comparison Between Two Ovulation Induction Therapies and LOD on Clinical Outcomes in CC-Resistant PCOS Women
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting 4-8% of reproductive-aged women and is a leading cause of infertility due to oligo-anovulation (1). Studies suggest a higher prevalence of 17.8-19.9% based on Rotterdam diagnostic criteria. PCOS is diagnosed by the presence of at least two out of three criteria: oligo- and/or anovulation, hyperandrogenism, and polycystic
Study InterventionsGonadotropin, Letrozole, laparoscopic ovarian drillingPrimary Endpointspregnancy rateStudy Period2020-01-01 → 2024-01-31 The Effect of Fasting on ICSI Outcomes in Patients With Polycystic Ovary Syndrome
Design and protocol of PCO fasting research:
This study is a pilot prospective, single-blinded (to the health assessor), randomized controlled trial conducted at the In Vitro Fertilization ( IVF) center of the Department of Obstetrics \& Gynecology, Kasr El-Ainy Hospital, Cairo University, Egypt, from October 2018 to September 2019, to determine the clinical effect of fasting on ICSI outcomes in
Study InterventionsFastingPrimary EndpointsRate of clinical pregnancyStudy Period2018-10-14 → 2022-09-01 Poor Responders Infertile Patients -A Great Clinical Challenge
infertile , poor responders patients who underwent ICSI. The participants were divided into 2 groups according to the starting dose of Gn stimulation. Group I started with 4 ampoules while group II started with 6 ampoules
Study InterventionsGonadotropinsPrimary Endpointsnumber of retrieved oocytesStudy Period2018-01-11 → 2018-06-04 Human Menopausal Gonadotropin Research in Infertility Assessing Cumulative Live Birth With Frozen Embryo Transfer.
The goal of this multicenter, randomized, placebo-controlled, double-blind clinical trial is toto evaluate the efficacy and safety of a human menopausal gonadotropin (hMG) in the development of multiple follicles, pregnancy, and cumulative live birth as part of an Assisted Reproductive Technology (ART) cycle in in women with a diagnosis of infertility.
Study InterventionshMG subcutaneous injection, PlaceboPrimary Endpointscumulative live birth rateStudy Period2025-11-01 → 2028-11