Insulin Treatment in Diabetic Older People With Heart Failure.
Cardiac failure (HF) and type 2 diabetes mellitus (T2DM) are two clinical conditions with a significant impact on public health worldwide. In the elderly population the prevalence of T2DM is constantly increasing as well as its incidence in all Western countries including Italy. The combination of HF and T2DM is frequent and leads to an increased risk of death and of non-fatal adverse cardiovascul
Study InterventionsInsulinPrimary EndpointsChange in blood glucose variabilityStudy Period2018-11-08 → 2019-09-18 Measuring Amino Acid and Glucose Metabolism in Healthy Volunteers and NAFLD Patients Using Total-body PET
This observational study aims to quantify whole-body amino acid and glucose metabolism in healthy adults and in patients with non-alcoholic fatty liver disease (NAFLD) using total-body PET/CT. The study investigates how orally and intravenously administered PET tracers (18F-FDG and 18F-FET) are absorbed in the gastrointestinal tract, distributed across major organs, and metabolized in different ph
Study Interventions18F-FDG (oral), 18F-FDG (intravenous), 18F-FET (oral)Primary EndpointsWhole-body tracer uptake (SUVmean) assessed using total-body PET/CTStudy Period2024-11-05 → 2027-10 Location of GLP-1 Release
Background: Physicians do not have a unified, scientifically tested theory of causation for obesity and its comorbidities, nor do they have explanations for the mechanics of the metabolic/bariatric surgery procedures. Integral to proffered hypotheses are the actions of the hormones glucagon-like peptide (GLP-1), peptide YY (PYY), and leptin.
Study objective: To obtain blood levels of GLP-1, PYY,
Primary EndpointsGLP-1; peptide YY (PYY)Study Period2011-11 → 2013-10 Effects of Early Exercise Rehabilitation in Severe Burns
BACKGROUND:
Postburn changes in glucose and protein metabolism are at their peak during the acute phase of severe burns. The resulting metabolic derangements lead to substantial muscle wasting, insulin resistance, which ultimately hampers full recovery and reintegration into society.
PURPOSE:
This randomized controlled trial was initiated to investigate the effects of exercise-based rehabilitat
Study InterventionsExercise, Standard of CarePrimary EndpointsChange in quadriceps muscle layer thickness (QMLT); Change in rectus femoris cross sectional area (RF-CSA)Study Period2019-11-25 → 2021-10 Efficacy and Safety of Ursodeoxycholic Acid (UDCA) Added to the DPP-4 Inhibitor in People With Type 2 Diabetes and Chronic Liver Diseases
1\. Objectives
1. To test whether Ursodeoxycholic Acid (UDCA) increases Glucagon-like peptide-1 (GLP-1) response to nutrients and improves glycemic control in people with type 2 diabetes.
2. To test whether sitagliptin enhances UDCA-induced beneficial effect in GLP-1 levels and glycemic control.
3. To test safety of combination therapy of sitagliptin and UDCA in people with type 2 diabetes.
2\.
Study InterventionsUDCA, SitagliptinPrimary Endpointsthe difference of haemoglobin A1c (HbA1c) and glycoalbumin (GA)Study Period2010-04 → 2013-03 A Study to Evaluate the Efficacy and Safety of MEDI0382 in the Treatment of Overweight and Obese Subjects With Type 2 Diabetes
This study is designed to evaluate the dose range for MEDI0382 with respect to blood glucose control and weight loss effects, as well as to further explore the safety profile of MEDI0382
Study InterventionsMEDI0382 low dose, MEDI0382 mid dose, MEDI0382 high dosePrimary EndpointsChange in HbA1c; Percent Change in Body WeightStudy Period2017-08-02 → 2019-06-14 Effects of Empagliflozin on Endogenous Glucose Production in End Stage Renal Disease(ESRD).
A study of the effects of empagliflozin, a SGLT-2 inhibitor, on endogenous glucose production and plasma glucagon levels in patients with end-stage renal disease (ESRD)
Study InterventionsEmpagliflozin, PlaceboPrimary EndpointsChanges in plasma Glucose levelStudy Period2018-09-10 → 2020-03-15 Impact of a Pro-diversity Gut Microbiota Diet After a Bariatric Surgery on Gut Microbiota, Eating Behaviour and Sensory Function
Bariatric surgery is the most effective treatment for long-term weight loss and reducing obesity-related health risks. It alters the gastrointestinal tract as well as metabolic and hormonal functions, influencing eating behaviour. However, weight loss outcomes and long-term maintenance vary between patients, likely due to changes in the gut microbiota. Dietary recommendations aimed at improving mi
Study InterventionsNutritional counselingPrimary EndpointsMicrobiota diversity 12 months after surgeryStudy Period2025-11-05 → 2029-04-05 The Impact of a High Protein Diet on Substrate Oxidation and Energy Metabolism
In the 19th century, researchers found out that the differences in the energy content of macronutrients (protein, carbohydrate and fat) can elicit different responses in the amount of calories individuals burn per day. It was demonstrated that protein has a metabolic advantage when compared to the other macronutrients (carbohydrate and fat). Since these findings, researchers all over the world sta
Study InterventionsDietPrimary EndpointsDifference in fat balance assessed by indirect calorimetry during 32 hours of a high-protein (HP) total diet replacement compared to 32hours of a control (CON) diet.Study Period2016-10 → 2018-03 Efficacy Study of Glucagonlike Peptide-1 to Treat Reperfusion Injury
The investigators planned to research the cardioprotective effects of intravenous liraglutide on reperfusion injury.
Study Interventionsliraglutide (Novo Nordisk, Bagsværd, Denmark), liraglutide placebo (Novo Nordisk)Primary Endpointsthe salvage index measured by cardiac magnetic resonanceStudy Period2013-11 → 2016-03