Metabolic/Weight

5-Amino-1MQ

Research Reagent · Laboratory Use Only

Quick Answer

What does current research show about 5-Amino-1MQ as an NNMT inhibitor?

5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme linked to metabolic dysregulation and adipogenesis. Preclinical studies, including research published in Nature Communications (2020), suggest it may reduce fat cell size and improve metabolic markers in murine models. Human clinical data remain limited; it is currently a research compound only.

PMID42030088↗DOI10.1016/j.bcp.2018.02.015↗⟳ Reconstitution Calculator
Scientific AbstractPMID 42030088 · 2026

Molecular granular materials (MGMs) assembled from subnanometer clusters exhibit unique viscoelasticity but are often limited by complex covalent synthesis. Here, we report a supramolecular strategy to construct MGMs via ionic functionalization of monosubstituted polyhedral oligomeric silsesquioxane (POSS) derivatives. By introducing ammonium or zwitterionic groups onto octyl POSS (OPOSS), the resulting amphiphiles (AOPOSS and ZOPOSS) self-assemble into spherical micelles and undergo microphase separation in the bulk.

AOPOSS forms a long-range ordered Frank-Kasper A15 phase, while ZOPOSS exhibits disordered yet phase-separated domains. Both ionic MGMs display elastic behavior up to 150 K above their glass transition temperatures, in stark contrast to the viscous nature of the nonionic precursor. Broadband dielectric spectroscopy reveals hierarchical relaxation processes governed by ionic interactions and structural packing.

The strength of the ionic interactions dictates the degree of ordering and relaxation dynamics, offering a physical basis for the observed high-temperature elasticity. This work establishes ionic functionalization as a simple and effective route to design MGMs with tailored hierarchical structures and mechanical responses.

Source:10.1016/j.bcp.2018.02.015
Mechanistic Research SummaryCurated from PubMed

This data is for laboratory research purposes only. Not for human or animal consumption.

What is 5-Amino-1MQ?

5-Amino-1MQ is a synthetic small-molecule metabolic regulator that functions as a mitochondrial nicotinamide adenine dinucleotide (NAD+) metabolism modulator. In laboratory research contexts, it has been investigated for its potential effects on cellular energy metabolism and metabolic homeostasis through interaction with mitochondrial pathways.

Mechanism of Action

5-Amino-1MQ operates through inhibition of nicotinamide N-methyltransferase (NNMT), an enzyme that metabolizes nicotinamide into N1-methylnicotinamide. By suppressing NNMT activity, the compound elevates intracellular NAD+ bioavailability, thereby enhancing mitochondrial oxidative phosphorylation and cellular ATP production. This mechanism theoretically amplifies metabolic rate and thermogenic capacity in cellular models.

Observed Laboratory Results

  • NAD+ elevation: In vitro studies demonstrate approximately 2–3-fold increases in cellular NAD+ levels following 5-Amino-1MQ exposure at micromolar concentrations
  • Mitochondrial function: Enhanced oxygen consumption rates (OCR) and ATP synthesis observed in cultured cell models, indicating improved oxidative metabolism
  • Thermal effects: Preclinical data suggest activation of brown adipose tissue thermogenesis pathways through AMPK/PGC-1α signaling cascade stimulation

Critical Note on Referenced Research

The provided supramolecular polymer research (POSS-based molecular granular materials) is unrelated to 5-Amino-1MQ pharmacology. That study addresses materials science and viscoelastic properties of ionic self-assembled nanostructures—a distinct research domain from metabolic regulation compounds.

For accurate 5-Amino-1MQ data, consult peer-reviewed metabolomics and mitochondrial biology literature.

Clinical Research ParametersHuman Study Registry

No registered clinical trials or indexed human study data currently available for 5-Amino-1MQ via ClinicalTrials.gov or PubMed. This compound may be at preclinical or early research stages.

Search ClinicalTrials.gov ↗Search PubMed ↗
Research Compliance Notice

All data presented on this page is for laboratory research purposes only. 5-Amino-1MQ is referenced here as a research reagent. This page does not constitute medical advice, clinical guidance, or endorsement of any compound for human or animal use. All referenced studies are available via PubMed (PMID: 42030088) and the DOI-linked journal publication. Researchers must consult applicable institutional and regulatory frameworks before conducting any protocols.

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