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What is Selank (Fragment)?
Selank is an anxiolytic peptide compound investigated for its effects on brain functional connectivity, particularly in regions associated with anxiety regulation and cognitive processing. This neuroimaging study assessed its impact on resting-state fMRI connectivity patterns in healthy participants.
Mechanism of Action
Selank modulates functional connectivity within the limbic-cortical anxiety circuit, specifically altering communication between the right amygdala (anxiety processing center) and temporal-parahippocampal regions (emotional memory integration). The peptide's anxiolytic properties are hypothesized to operate through normalization of amygdala-prefrontal signaling pathways, reducing hyperactivity in threat-detection networks while preserving executive function integration via the dorsolateral prefrontal cortex (DLPFC).
Observed Laboratory Results
- Selective amygdala remodeling: Significant between-group differences in functional connectivity between the right amygdala and right fusiform gyrus, inferior/middle temporal gyri, and parahippocampal gyrus following Selank administration versus placebo
- Temporal dynamics: Post-injection fMRI measurements at 5 and 20 minutes revealed time-dependent changes in FC patterns, indicating active neurobiological responsiveness
- Differential peptide effects: Post hoc analysis demonstrated both general FC effects shared between Selank and Semax, plus compound-specific connectivity signatures in the right amygdala-temporal cortex circuit not previously documented
Study Parameters
N=52 healthy participants | 3-timepoint design (baseline, 5min, 20min post-injection) | ROI focus: bilateral amygdala, bilateral DLPFC | Imaging modality: resting-state fMRI