Neurological

Cortagen

Research Reagent · Laboratory Use Only

Quick Answer

What is Cortagen and what does research show about its effects on cortical neurons?

Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Pro) from the Russian Khavinson bioregulator series. Preclinical research demonstrates effects on cortical neuron gene expression, neuroplasticity support, and neuroprotection in stroke and traumatic brain injury models.

PMID21161681↗DOI10.1007/s10517-010-1067-0↗⟳ Reconstitution Calculator
Scientific AbstractPMID 21161681 · 2010

Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Pro) from the Russian Khavinson bioregulator series investigated for cortical neuron support and neuroplasticity in aging and post-injury models. Preclinical research demonstrates effects on gene expression in cortical neurons, regulation of growth factor signaling pathways, and neuroprotection in stroke and traumatic brain injury models. Cortagen is studied alongside Cortexin (a larger polypeptide complex) and Pinealon as part of the bioregulator pharmacological tradition.

Source:10.1007/s10517-010-1067-0
Mechanistic Research SummaryCurated from PubMed

This data is for laboratory research purposes only. Not for human or animal consumption.

What is Cortagen?

Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Pro) from the Khavinson bioregulator series investigated for cortical neuron function, neuroplasticity, and post-injury cognitive recovery.

Mechanism of Action

Cortagen is hypothesized to act through direct chromatin interaction in cortical neurons, modulating gene expression patterns associated with neuroplasticity and growth factor signaling.

Observed Laboratory Results

  • Cortical neuron gene expression modulation in aging brain models
  • Neuroprotection in stroke and TBI models
  • Growth factor pathway regulation in cortical tissue
  • Member of the Khavinson bioregulator family alongside Pinealon and Cortexin
Clinical Research ParametersHuman Study Registry

No registered clinical trials or indexed human study data currently available for Cortagen via ClinicalTrials.gov or PubMed. This compound may be at preclinical or early research stages.

Search ClinicalTrials.gov ↗Search PubMed ↗
Research Compliance Notice

All data presented on this page is for laboratory research purposes only. Cortagen is referenced here as a research reagent. This page does not constitute medical advice, clinical guidance, or endorsement of any compound for human or animal use. All referenced studies are available via PubMed (PMID: 21161681) and the DOI-linked journal publication. Researchers must consult applicable institutional and regulatory frameworks before conducting any protocols.

Related Compounds

Other Neurological Research Compounds

Semax
Alzheimer's disease, first described over a century ago, is currently among the most commo…
→
Selank
BACKGROUND: Primary Sjögren's disease (SjD) is a chronic autoimmune disease that predomina…
→
Cerebrolysin
Previous studies from our laboratory show that intraperitoneal injections of 1-metyl-4-phe…
→
Dihexa
BACKGROUND: Huntington's disease (HD) is a neurodegenerative disorder characterized by mot…
→
View all Neurological compounds →